Fibrin degradation products

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Sections available in full article Overview, Uses, Sampling, Source of test material, Quantity of test material, Sample collection technique, Quality control, Test (s), Methodologies, Result data, Normal (reference) values, Abnormal values, Sources, Vetstream contributor(s),
Contributors Dr Kathleen P Freeman DVM MS PhD MRCVS
Ms Jane Miller BVetMed FRCPath MRCVS

Overview

  • Plasmin acts on fibrin or fibrinogen → fibrin degradation products (FDPs).
  • Half life of FDPs in circulation is 9-12 h.
  • Accumulation of FDPs → hemostatic abnormalities.

Uses

In combination

  • Other tests for diagnosis of fibrinolysis, which may occur with DIC Disseminated intravascular coagulation , thrombus formation, internal bleeding or hematomas.

Result data

Normal (reference) values

  • <10 microg/ml.

Abnormal values

  • Increased in DIC Disseminated intravascular coagulation.
  • Increased levels → increased fibrinolytic activity and or reduced phagocytic removal of FDPs from circulation.
  • Increases - DIC, thrombosis, internal hemorrhage, hematomas.

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