Overview
- Produced primarily in pancreas, degraded and excreted by kidney.
Uses
In combination
- Diagnosis of pancreatitis
with amylase and TLI .
Result data
Normal (reference) values
- Varies with individual laboratories.
- Usually <300 IU/L.
- Example of reference interval - 13-200 IU/L.
- Laboratory should supply reference interval based on this method.
Abnormal values
Increased [lipase]
- Acute pancreatitis .
- Liver disease (unusual).
Errors and Artifacts
False increase
- Renal disease.
- Decreased glomerular filtrate.
- Severe hemolysis.
Frequently elevated in renal disease due to reduced clearance.. - Hyperbilirubinemia (measured by turbidometric method).
- Heparin (anticoagulant).
- EDTA (anticoagulant).
- Glucocorticoid therapy.
Sources
Publications
Refereed papers
- Simpson K W, Batt R M, McLean L et al(1989) Circulating concetrations of trypsin-like immunoreactivity and activities of lipase and amylase after pancreatic duct ligation in dogs. Am J Vet Res 50 , 629.
- Hall T A & Macy D W (1988) Acute pancreatitis. Comp Cont Educ Pract Vet 10 , 403.
Other sources of information
- Ettinger S J & Feldman E C (eds) (2000) Textbook of Veterinary Internal Medicine. 5th edn. Philadelphia: W B Saunders & Co.
- Kaneko J J, Harvey J W & Brass M L (eds) (1997) Clinical Biochemistry of Domestic Animals. 5th edn. Boston: Academic Press.
- Duncan J R, Prasse K W & Mahaffey E A (1994) Veterinary Laboratory Medicine. Clinical Pathology. 3rd edn. Iowa: Iowa University Press.
