Selegiline hydrochloride

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Sections available in full article Name, Class of drug, Uses, Administration, Routes of administration, Dosage, Timing of administration, Pharmocokinetics, Physiological, variations, Pathological variations, Precautions, Contra-indications, Use with care, Interactions, Adverse reactions, Sources, Publications,
Contributors

Name

  • Selegiline.

Class of drug

  • Alpha-2-agonist.

Uses

Action

  • Selective and irreversible monoamine oxidase inhibitor.

Indications

  • Treatment of Canine Cognitive Dysfunction (Cognitive Dysfunction Syndrome) Canine cognitive dysfunction syndrome (CDS).
  • Treatment of behavioral disorders of emotional origin, such as depression and anxiety.
  • In association with behavioral therapy for treatment of signs of emotional origin observed in behavioral conditions eg overactivity, separation anxiety, phobias and unsociable behavior Lack loss of or inadequate housetraining.
  • Unlicensed use in the cat as MAOB inhibitor and behavior modifier.
  • In USA licensed for use in treatment of uncomplicated pituitary-dependent hyperadrenocorticism Hyperadrenocorticism (up to 50% cases may fail to respond).

Adverse reactions

Other reported reactions

  • Salivation.
  • Weight loss.
  • Decreased pupillary light response.
  • Panting.
  • Sterotypical behavior.
  • Dehydration.
  • Pruritus.
  • Licking.
  • Trembling.
  • Diarrhea.
  • Vomiting.
  • Lethargy.
  • Disorientation.

Treatment

  • Diarrhea, vomiting, lethargy, disorientation.

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