Carboplatin

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Sections available in full article Name, Class of drug, Description, Uses, Administration, Do not mix with, Routes of administration, Dosage, Pharmocokinetics, Normal, Precautions, Contra-indications, Use with care, Adverse reactions, Sources, Publications,
Contributors Dr William Brewer Jr DVM DiplACVIM Oncology and Internal Medicine
Synonyms Paraplatin

Name

  • Carboplatin.

Class of drug

  • Platinum compound antineoplastic agent.
  • Alkylating type agent.

Uses

Action

  • Cell cycle non-specific antineoplastic agent - an analogue of cisplatin.
  • Intracellular carboplatin binds to DNA to form intra- and interstrand crosslinks and DNA-protein crosslinks.

Indications

  • Used against various carcinomas and sarcomas.
  • Increases the survival time when used as an adjunct to amputation in dogs with appendicular osteosarcoma.

Adverse reactions

Other reported reactions

  • In dogs adverse effects of carboplatin include nephrotoxicity, myelosuppression and electrolyte abnormalities.

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