Sodium valproate

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Sections available in full article Name, Class of drug, Uses, Administration, Routes of administration, Dosage, Precautions, Interactions, Adverse reactions, Sources, Publications,
Contributors Dr Kyle Braund BVSc MVSc PhD FRCVS DipACVIM
Synonyms Epilim

Name

  • Sodium valproate

Class of drug

  • Anticonvulsant.

Uses

Action

  • The mechanism of this drug's anticonvulsant activity is unclear.
  • May increase levels of gamma amino benzoic acid.
  • The drug's short half-life in dogs, potentially serious hepatic toxicity and lack of efficacy make it a third line agent in dogs.

Indications

  • Convulsions Epilepsy: idiopathic.
  • May be useful in combination with other anticonvulsant drugs.

Adverse reactions

Other reported reactions

  • Hepatotoxicity (serious) and gastrointestinal disturbances (common).

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