Glycopyrronium

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Sections available in full article Name, Class of drug, Uses, Administration, Routes of administration, Dosage, Precautions, Interactions, Adverse reactions, Sources, Publications,
Contributors Dr Sheilah Robertson BVMS(Hons) PhD DipACVA DipECVA MRCVS

Name

  • Glycopyrronium bromide.

Class of drug

  • Antimuscarinic agent.

Uses

Action

  • Decreases oral and bronchial secretions and inhibits vagal efferent activity.
  • Also blocks the peripheral muscarinic actions of neostigmine Neostigmine and pyridostigmine Pyridostigmine.

Indications

  • Used pre-operatively to decrease oral and bronchial secretions and block vagal inhibitory reflexes.
  • Its routine use for pre-anesthetic medication in dogs is controversial.
  • In conjunction with long-acting anticholinesterase drugs, eg neostigmine, pyridostigmine during antagonism of neuromuscular block.

Adverse reactions

Other reported reactions

  • Adverse reactions limited by reduced ability to cross blood brain or placental barrier.
  • Low dose may produce paradoxical heart rate slowing before desired response supervenes.
  • Sinus tachycardia.
  • Ileus.
  • Urinary retention.
  • Drying of bronchial secretions.

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