Cisplatin

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Sections available in full article Name, Class of drug, Uses, Administration, Routes of administration, Dosage, Timing of administration, Pharmocokinetics, Normal, Precautions, Contra-indications, Use with care, Interactions, Adverse reactions, Sources, Publications,
Contributors Dr William Brewer Jr DVM DiplACVIM Oncology and Internal Medicine

Name

  • Cisplatin.

Class of drug

  • Platinum compound antineoplastic agent Chemotherapy: general principles.
  • Alkylating type agent.

Uses

Action

  • Alkylating action.
  • It is a platinum complex that binds to DNA to form intra- and interstrand crosslinks and DNA-protein crosslinks.

Indications

  • Cell cycle non-specific antineoplastic agent against various sarcomas and carcinomas.
  • Used most commonly in the management of osteosarcoma OsteosarcomaOsteosarcoma: axial skeleton .

Adverse reactions

Other reported reactions

  • Nephrotoxicity (major concern), myelosuppression, nausea, vomiting, electrolyte abnormalities, ototoxicity, neurotoxicity, hyperuricemia and anaphylactic reactions.

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