Name
- Protamine sulfate.
Class of drug
- Anticoagulant.
Uses
Action
- Protamine sulfate is an anticoagulant.
-
When it is administered in the presence of heparin a stable salt is formed causing the loss of anticoagulant activity of both compounds.
Indications
- The effects of heparin
are neutralized within five minutes of protamine administration with the effect persisting for approximately two hours. - Protamine is indicated for the treatment of heparin overdosage.
Adverse reactions
Other reported reactions
- Adverse effects in humans include anaphylaxis, hypotension, bradycardia, nausea, vomiting and lassitude.
