Name
- Metronidazole.
Class of drug
- Synthetic nitroimidazole.
Uses
Action
- Antibacterial and antiprotozoal activity.
- May have effects on the immune system by modulating cell-mediated immune responses.
- Mechanism of action on protozoans unknown but in bacteria it appears to be reduced spontaneously under anaerobic conditions to compounds that bind to DNA and cause cell death.
Indications
- Anaerobic infections, eg Bacteroidesspp
, Clostridiumspp , etc giardiasis and other protozoal infections. - Management of hepatic encephalopathy .
- Spiramycin is active against gram-positive aerobes including Staphylococcusspp , Streptococcusspp , Bacillusspp, Actinomycesspp , Clostridiumspp and Bacteroidesspp.
- Appetite stimulant in reptiles.
- Adjunct to treatment of pyothorax .
Adverse reactions
Other reported reactions
- Adverse effects uncommon:
- Vomiting.
- Nystagmus.
- Ataxia.
- Knuckling.
- Head tilt.
- Seizures.
- Hepatotoxicity.
- Hematuria.
