Name
- Cimetidine.
Class of drug
- H2-antihistamine.
Uses
Action
- H2 receptor antagonist.
- Prevents activation of suppressor T cells by histamine.
Indications
- Gastric
and duodenal ulcers. - Uremic gastritis.
- Stress or drug-related erosive gastritis.
- Esophagitis .
- Hypersecretory conditions secondary to gastrinoma or mastocytosis .
- Adjunctively to reverse metabolic alkalosis .
- May be useful as an immunomodulating agent by preventing activation of suppressor T cells by histamine although evidence is lacking.
Adverse reactions
Other reported reactions
- Cardiac arrhythmias and hypotension (IV route).
- Hepatotoxicity and nephrotoxicity.
- Adverse effects are rare in animals; headache, gynecomastia and decreased libido in humans.
Treatment
- If used by the IV route, administer over 30 min to prevent cardiac arrhythmias and hypotension.
