Control of canine leishmaniosis

Introduction

• Several species of Leishmania have been reported in dogs, the major veterinary concern is infection by Leishmania infantum/chagasi .
• Domestic dogs are the major reservoir of infection for humans so campaigns to control canine leishmaniasis (CanL) have been primarily geared towards reduction of the risk of human infection rather than solving an important canine welfare problem.
• Treatment is expensive and although there is good clinical response in the majority of dogs with leishmaniosis, low level infection may persist despite therapy.
• The only fully successful control campaign involved the elimination of all dogs in eastern China, an outmoded strategy that is no longer acceptable in that country or elsewhere.
• In Brazil, a temporary fall in CanL was seen following the culling of seropositive dogs in small urban areas. However, large scale attempts were abandoned because of cost and the difficulty in maintaining a dog population with a low density of infection. In particular, preventing the re-introduction of susceptible dogs to replace those culled, was difficult to control.
• In Italy, treatment of dogs with clinical leishmaniosis using the pentavalent antimonial, meglumine antimoniate (Glucantime®, Merial) reduced the prevalence of CanL. However, parasites isolated from dogs with relapses displayed resistance to the drug and, as pentavalent antimonials are the drugs of choice to treat human cases, this approach is not sustainable.
• Current means of control are aimed at the sand fly vectors.
• CaniLeish® (the first vaccine against CanL registered by the European Medicines Agency in 2011 by Virbac) has been developed to vaccinate dogs from six months of age to reduce the risk of developing an active infection and clinical disease after contact with Leishmania infantum. It is to be used only in leishmania-negative dogs.

Sources

Publications

Refereed papers

• Recent references from PubMed.
• Solano-Gallego L, Miró G, Koutinas A, Cardoso L, Pennisi M G, Ferrer L, Bourdeau P, Oliva G, Baneth G (2011) LeishVet guidelines for the practical management of canine leishmaniosis. Parasit Vectors 4 , 86 PubMed.
• Ferroglio E, Poggi M, Trisciuoglio A (2008) Evaluation of 65% permethrin spot-on and deltamethrin-impregnated collars for canineLeishmania infantum infection prevention. Zoonoses Public HealthApr; 55 (3), 145-148 PubMed.
• Miro G, Galvez R, Mateo M, Montoyo A, Descalzo M A, Molina R (2007) Evaluation of the efficacy of a topically administered combination of imidacloprid and permethrin against Phlebotomus perniciosus in dog. Vet Parasitol 143 (3-4), 375-379 PubMed.
• Molina R, Miro G, Galvez R, Nieto J, Descalzo M A (2006) Evaluation of a spray of permethrin and pyriproxyfen for the protection of dogs against Phlebotomus perniciosus. Vet Rec 159 (7), 206-209 PubMed.
• Palatnik-de-Sousa C B, Batista-de-Melo L M, Borja-Cabrera G P, Palatnik M, Lavor C C (2004) Improving methods for epidemiological control of canine visceral leishmaniosis based on a mathematical model. Impact of the incidence of the canine and human disease. An Acad Bras Cienc 76 , 583-593 PubMed.
• Reithinger R et al(2004) Are insecticide impregnated dog collars a feasible alternative to dog culling as a strategy for controlling canine visceral leishmaniosis in Brazil. Int J Parasitol 34 , 55-62 PubMed.
• Mazloumi Gavgani A S, Hodjati M H, Mohite H & Davies C R (2002) Effect of insecticide-impregnated dog collars on incidence of zoonotic visceral leishmaniasis in Iranian children: a matched-cluster randomised trial. The Lancet 360, 374-379.
• Chen S, Li F, He J, Chen X, Wang D, Wei L, Yang H & Guan L (2001) Experimental study on prevention of dog-sand fly contact by deltamethrin collar. End Dis Bull 16 (3), 17-19. (Chinese).
• David J R, Stamm L M, Bezarra H S, Nonato Souza, R, Killick-Kendrick R & Oliveira Lima J W (2001) Deltamethrin-impregnated plastic dog collars have a potent anti-feeding effect on Lutzomyia longipalpis and Lutzomyia migonei. Mem Inst Oswaldo Cruz 96, 839-847.
• Maroli M, Mizzon V, Siragusa C, D'Orazi A & Gradoni L (2001) Evidence for an impact on the incidence of canine leishmaniasis by the mass use of deltamethrin-impregnated dog collars in southern Italy. Med Vet Entomol 15, 358-363.
• Molina R, Lohse J-M & Nieto J (2001) Evaluation of a topical solution containing 65% permethrin against the sandfly (Phlebotomus perniciosus) in dogs. Vet Ther 2, 261-267.
• Reithinger R, Teodoro U & Davies C R (2001) Topical insecticide treatments to protect dogs from sand fly vectors of leishmaniasis. Emerg Infect Dis 7, 872-876.
• Halbig P, Hodjati M H, Mazloumi-Gavagni A S, Mohite H & Davies C R (2000) Further evidence that deltamethrin-impregnated collars protect domestic dogs from sandfly bites. Med Vet Entomol 14, 223-226.
• Killick-Kendrick R, Killick-Kendrick M, Focheux M C, Dereure J, Puech M P & Cadiergues M C (1997) Protection of dogs from bites of phlebotomine sandflies by Scalibor ProtectorBands for control of canine leishmaniasis. Med Vet Entomol 11, 105-111.

Other sources of information

• European Medicines Agency : http://www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/veterinary/medicines/002232/vet_med_000234.jsp&mid=WC0b01ac058001fa1c
• Advanced management of Canine Leishmaniosis. Proceedings of the Southern European Veterinary Conference (SEVC) 2011 Symposium, Barcelona, Spain. September 30, 2011.
• Killick-Kendrick R & Watson T (Eds) (2002) Proceedings of the 2nd International Forum on Canine Leishmaniasis, Seville, 6-9 February, 2002. Boxmeer: Intervet International.
• Ascher F, Alves-Pires C, Campos C, Capela M J & Aguiar P (1997) Effet protecteur d'un spray insecticide contre Phlebotomus perniciosus vecteur de leishmaniose. In: Conférence Nationale des Vétérinaires Specialisés en Petits Animaux (CNVSPA), Paris, November 1997, 3pp.