Canine epileptoid cramping syndrome

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Sections available in full article Introduction, Presenting signs, Geographic incidence, Age predisposition, Breed predisposition, Pathogenesis, Predisposing factors, Pathophysiology, Timecourse (incubation, duration), Diagnosis, Client history, Clinical signs, Diagnostic investigation, Confirmation of diagnosis, Histopathology findings, Differential diagnosis, Treatment, Initial symptomatic treatment, Standard treatment, Sequelae, Prognosis, Expected response to treatment, Sources, Publications, Vetstream contributor(s),
Contributors Professor Dennis O'Brien DVM PhD
Synonyms CECS, Spikes disease

Introduction

  • First recognized in 1997 by German veterinarian Diana Plange after a number of dogs bred by a single breeder were affected. Recognized in 1999 in the US.
  • Cause : unknown.
  • Signs : cramping episodes with normal attitude between episodes.
  • Treatment : symptomatic, although some dogs respond to hypoallergenic diets.
  • Diagnosis : usually based on history, signs and ruling out other conditions.
  • Prognosis : generally good as not life-threatening and episodes do not appear to progress.

Diagnosis

Clinical signs

  • These involuntary movements usually require a degree of exercise or stress before they occur.
  • Like in other breed-related movement disorder, the clinical presentation consists of a combination of chorea (abrupt and nonsustained contraction of different muscle groups and dystonia (involuntary sustained contraction of a group of muscle) - severe trembling, staggering - drunken appearance.
  • As further episodes occur muscle cramping more obvious - usually affects hind limbs and tail may curl up.
  • Exaggerated stretching.
  • Some dogs unable to stand.
  • Borborygmi.
  • Lip smacking or licking.
  • Episodes last seconds to 30 minutes.
  • No loss of consciousness.

Diagnosis

Differential diagnosis

  • Epilepsy Epilepsy: idiopathic.
  • Microvascular disorders.
  • Back pain.
  • Irritable bowel syndrome (for abdominal form) Diarrhea: chronic - psychological functional.

Sequelae

Prognosis

  • Episodes tend to remain with same severity throughout life ie no progression of signs.

Expected response to treatment

  • May become asymptomatic with dietary control.

Sources

Publications

Refereed papers

  • Recent references from PubMed.

Other sources of information

  • Investigation is being carried out at the Department of Clinical Sciences of Companion Animals at Utrecht University, the Netherlands:

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