1080 poisoning

Sodium monofluoroacetate toxicosis • SMFA poisoning

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  • Highly toxic pesticide, under strict control in the US and UK. Widely used in New Zealand and Australia by licensed authorities to control pest animals. Dogs are highly susceptible.


Clinical signs

  • Anxiety, hyperexcitability.
  • Hyperirritability.
  • Running.
  • Howling.
  • Vomiting.
  • Urination, defecation and tenesmus.
  • Cycles of tonic and/or clonic convulsions.
  • Weakness and ultimately death from exhaustion.

Differential diagnosis



  • Prognosis is poor to grave once clinical signs have developed.

Expected response to treatment

  • Treatment is usually begun too late to save the dog.

Reasons for treatment failure

  • Serious and rapidly-progressing nature of toxicosis.
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