Fibrosarcoma

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Sections available in full article Introduction, Presenting signs, Age predisposition, Breed predisposition, Pathogenesis, Etiology, Pathophysiology, Diagnosis, Presenting problems, Client history, Clinical signs, Diagnostic investigation, Confirmation of diagnosis, Gross autopsy findings, Histopathology findings, Differential diagnosis, Treatment, Standard treatment, Monitoring, Sequelae, Prognosis, Reasons for treatment failure, Sources, Publications, Vetstream contributor(s),
Contributors Dr Ruthanne Chun DVM DipACVIM
Synonyms FSA

Introduction

  • Malignant, locally invasive tumor of mesenchymal cells.
  • Sites: axial skeleton and flat bone (pelvis and scapular), subcutaneous tissues anywhere on body.
  • Signs : firm, subcutaneous mass; may involve underlying skeletal muscle or bone.
  • Metastasis - uncommon.
  • Diagnosis : histopathology, radiography, cytology.
  • Treatment : amputation/surgical resection, aiming for 3-5 cm margins around tumor and on fascial plane deep to gross tumor (difficult - invasive).
  • Prognosis : recurrence rate high following incomplete resection - better following amputation.

Diagnosis

Clinical signs

  • Palpable, firm, subcutaneous mass - may involve deep tissues.

Diagnosis

Differential diagnosis

  • Other neoplasia, eg primary bone tumors Bone: neoplasia , hemangiopericytoma Hemangiopericytoma , mast cell tumor.
  • Injury.
  • Abscess.
  • Other oral tumors Mouth: neoplasia.
  • Other nasal tumors Nasal cavity: neoplasia.
  • Osteomyelitis Osteomyelitis.
  • Hematoma Ear: aural hematoma.

Sequelae

Prognosis

  • Potential cure with aggressive surgery +/- radiation therapy.
  • Recurrence rate high following incomplete resection (locally invasive).

Reasons for treatment failure

  • Inadequate resection.
  • Distant metastasis prior to presentation for treatment, or following local therapy in a low number of cases.

Sources

Publications

Refereed papers

  • McChesney S L, Withrow S J et al(1989) Radiotherapy of soft tissue sarcomas in dogs. JAVMA 194 (1), 60-63.
  • Weinstein M J, Carpenter J L et al(1989) Nonangiogenic and nonlymphomatous sarcomas of the canine spleen - 57 cases (1975-1987). JAVMA 195 (6), 784-788.

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