Amyloidosis

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Introduction

  • Rare conditions with abnormal proteinaceous deposits within tissues.
  • Cause : familial disease in Abyssinians or Siamese or secondary to chronic inflammation.
  • Signs : related to organ affected. May be localized or systemic.
  • Diagnosis : histopathology, special staining and immunohistochemistry.
  • Treatment : few options.
  • Prognosis : guarded, usually progressive.

Diagnosis

Clinical signs

  • Kidneys small and irregular (chronic stage).
  • Dehydration.
  • Dyspnea (if pulmonary thrombosis).
  • Hindleg paralysis (if aortic thrombosis).

Diagnosis

Differential diagnosis

  • Other causes of chronic renal failure    .
  • Thromboembolism due to cardiomyopathy.

Outcomes

Prognosis

  • Poor: usually progressive deposition.

Expected response to treatment

  • Improvement in clinical signs.
  • Lack of progression of disease.

Reasons for treatment failure

  • Disease usually progressive.
  • Presence of underlying chronic renal failure.
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